William Dameron Guthrie (1859, San Francisco, California – 1935) was an American lawyer and educator. He was educated in Paris, in England, and at the Columbia Law School (1879-80). In his practice before the United States Supreme Court he argued the income tax, California irrigation, Illinois inheritance tax, oleomargarine, and Kansas City stockyards rate cases. He was Storrs lecturer at Yale University in 1907-08 and was Ruggles Professor of Constitutional Law at Columbia University from 1908-22. Besides his contributions to periodicals on legal and political subjects, he was author of Lectures on the Fourteenth Amendment to the Constitution (1898) and Introduction to American Constitutional Law (1913).
Guthrie served as president of the Association of the Bar of the City of New York from 1925 to 1927. Guthrie also served as a lawyer to the Rockefeller family.